Meanwhile, New Zealand
![Image](https://i.imgur.com/jU9NTy2.jpg)
With the duration of protection and the lag in vaccination (ie. the date of first person vaccination to date of last person vaccinated), will herd immunity ever be achieved?
I think I'm running out of patience, lol. You're right. I'm crabby about having to get a shot after people who are at risk because of their own choices.
The group treating this mechanism utilizes:
Nicotinic acid aka Niacin (most important and not nicotinamide or other forms) — 100mg
Vitamin C aka Ascorbic Acid — 1500mg
Vitamin D — 3000iu
Zinc — 15mg
Selenium — 50mcg
Quercetin — 500mg
Honestly, much of the article goes over my head, but it sounds reasonable. Someone with more biology here might be able to vet it better. Regardless, the vitamins themselves are cheap and easily had so I got some. It is shocking how hard it is to find Nicotinic acid versus the other forms.Their research, COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity, has received an excellent response and seems to be validated in mice, relevant abnormalities found in ferrets and the mechanism echoed by other researchers. Dysfunction of relevant systems are found in COVID19 and correlated with inflammatory markers. Clinical trials are under way to treat the same mechanism using more exotic and commercial compounds than the simple ones used with success in their case.
According to this theory, cofactors coupled to the oxidation/NAD+ cascade are critical to outcomes and this is seen in the observation that low selenium levels correlated to poor outcomes in China. Observations of high blood sugar being a predictor of death in COVID19 patients, regardless of diebetic status validate metabolic changes being a major risk factor of COVID19 according to NAD+ theory. Activation of the same kynurenine pathways predicted in NAD+ theory of COVID19 correlate to blood sugar deregulation.
Unrelated to the core mechanism, a recent publication in the journal Nature, stated: “vitamin B3 (niacin or nicotinamide) is highly effective in preventing lung tissue damage. It might be a wise approach to supply this food supplement to the COVID-19 patients.” A recent bioinformatics analysis also indicated niacin should be studied as a treatment for COVID19. A forward looking pre-print indicates nicotinic acid may act as a one of a kind bioenergetic “pump” of inflammatory molecules out of cells, critical for COVID19. Niacin has been seen to easily cure systematic NAD+ deficiency in clinical research. In 2010, this exact biochemical cascade surrounding NAD+ has been speculated as an HIV cascade in the paper, “The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis”. Interestingly, the well respected Open Medicine Foundation collaborated with bioinformatics companies and scientists from leading universities to develop the Metabolic Trap theory of Chronic Fatigue Syndrome/ME which looks to be a leading theory based on the same mechanisms presented here.
It has also been deemed to be safe - and offer complete protection against hospitalisation and death.
In a comment published alongside the Lancet paper, Profs Ian Jones and Polly Roy said: "The development of the Sputnik V vaccine has been criticised for unseemly haste, corner cutting, and an absence of transparency.
Dr Julian Tang, a clinical virologist at the University of Leicester, said: "Despite the earlier misgivings about the way this Russian Sputnik V vaccine was rolled out more widely - ahead of sufficient Phase 3 trial data - this approach has been justified to some extent now.
"Such pandemic-related vaccine rollout compromises have, to be fair, been adopted in the UK vaccination programme also - with the extended intervals between the first and second doses.
"So we should be more careful about being overly critical about other countries' vaccine designs."
My understanding is the UK has been doing a lot of sequencing of the virus as it spreads, half of all sequencing in the world. This might well explain why it was spotted in the UK first.
https://www.wsj.com/amp/articles/as-va ... 1612693803“Going through the five phases of grief, we need to come to the acceptance phase that our lives are not going to be the same,” said Thomas Frieden, former director of the U.S. Centers for Disease Control and Prevention. “I don’t think the world has really absorbed the fact that these are long-term changes.”