COVID-19

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CS
Posts: 554
Joined: Sat Dec 29, 2012 10:24 pm

Re: COVID-19

Post by CS »

Study on using plasma:
https://jamanetwork.com/journals/jama/f ... le/2763983
Results All 5 patients (age range, 36-65 years; 2 women) were receiving mechanical ventilation at the time of treatment and all had received antiviral agents and methylprednisolone. Following plasma transfusion, body temperature normalized within 3 days in 4 of 5 patients, the SOFA score decreased, and Pao2/Fio2 increased within 12 days (range, 172-276 before and 284-366 after). Viral loads also decreased and became negative within 12 days after the transfusion, and SARS-CoV-2–specific ELISA and neutralizing antibody titers increased following the transfusion (range, 40-60 before and 80-320 on day 7). ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment. Of the 5 patients, 3 have been discharged from the hospital (length of stay: 53, 51, and 55 days), and 2 are in stable condition at 37 days after transfusion.

Five minute test (similar to strep) getting rolled out next week. Someone said 70% accuracy, which might have been for the strep version, because I didn't see that mentioned in the announcement.
https://www.marketwatch.com/story/abbot ... 2020-03-27


Another test from the German company Bosch. 2.5 hours, No lab needed (but you have to buy their unit for low five figures), each test a reasonable cost. The reddit page has a link to the original article in German.
https://www.reddit.com/r/Coronavirus/co ... oduces_95/


Data about what social restriction were used with 1918 flu pandemic and the results for different cities in the US. As expected, Philadelphia was a mess. RIP Great Grandpa and family. The original article from the National Geographic is linked within. It is free with a signup (or perhaps an cloaked browser connection).
https://twitter.com/JoyceWhiteVance/sta ... 95264?s=20


CDC mask recommendations might change, from someone who might know.
https://twitter.com/DrMattMcCarthy/stat ... 19841?s=20


A hepa filter mask from your vacuum bag (cross posted)
https://youtu.be/W6d3twpHwis


There is speculation the virus could make young men sterile.
https://www.scmp.com/news/china/science ... t-male-sex
https://www.medrxiv.org/content/10.1101 ... 1.full.pdf
In a paper published on the preprint research platform medRxiv.org, the researchers – from Zhongnan Hospital of Wuhan University and the Hubei Clinical Research Centre for Prenatal Diagnosis and Birth Health – said they analysed blood samples from 81 men aged 20 to 54 who tested positive for the coronavirus and were hospitalised in January.
The median age of the participants was 38 and roughly 90 per cent of them had only mild symptoms. The samples were collected in the last days of their stay in hospital.
Using the samples, the team looked at the ratio of testosterone to luteinising hormone (T/LH). A low T/LH ratio can be a sign of hypogonadism, which in men is a malfunction of the testicles that could lead to lower sex hormone production.
The average ratio for the Covid-19 patients was 0.74, about half the normal level.

More on the underreporting going on
https://www.buzzfeednews.com/article/ni ... -hospitals
Doctors and nurses working in several hospitals around the country, who spoke with BuzzFeed News on the condition of not being named out of fear of repercussions, said that the official counts of COVID-19 related deaths are not comprehensive for three main reasons: a lack of tests and protective equipment means not everyone who contracted or dies of COVID-19 is diagnosed; overwhelmed hospitals may be running behind on reporting the numbers to state and county authorities; and some hospitals reporting their totals on a daily basis say they’re not being reflected promptly in county and state reports.
I would posit another reason - if they knowingly allow a ncovid patient in to get the treatment dollars then they could be liable. (I'm looking at you, radiation oncology)


Asymptomatic patients (apologies if I got this from this forum, I can't remember anymore)
https://twitter.com/fascinatorfun/statu ... 14887?s=20
https://www.wired.com/story/a-south-kor ... for-trump/
“In Daegu, we had more than 10k members of Shincheonji. When we tested those who were symptomatic, 87.5 % turned out to be positive. When we tested a sample of people who weren’t symptomatic, it was 74.4%”

An existing TB vaccine might help. Germany is rolling out study using healthcare workers. I thought I remembered reading the UK was doing a similar study but that might have been something else.
https://m.medicalxpress.com/news/2020-0 ... virus.html


In other news, my data sharing addiction is still going strong and I have 20k words to write in 7 days. Happy Sunday, everyone.

CS

CS
Posts: 554
Joined: Sat Dec 29, 2012 10:24 pm

Re: COVID-19

Post by CS »

More cool stuff for data geeks - Visualizing the History of Pandemics
Apparent the first graphic is updated regularly
https://www.visualcapitalist.com/histor ... deadliest/

Edit - it also has that excellent R0 graphic showing just how contagious measles is.

jacob
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Location: USA, Zone 5b, Koppen Dfa, Elev. 620ft, Walkscore 73
Contact:

Re: COVID-19

Post by jacob »

http://covid19.healthdata.org/

US state by state projections of the first wave including hospital, icu, and vent shortages. Also expected fatalities, peak dates, etc.

EdithKeeler
Posts: 1059
Joined: Sun Sep 01, 2013 7:55 pm

Re: COVID-19

Post by EdithKeeler »

“On The Media” this morning was very good—talked about the various articles coming out of about the virus and peer reviews, “armchair epidemiologists,” coverage by the media, etc. Worth a listen.
https://www.wnycstudios.org/podcasts/ot ... g-the-hero

Jason
Posts: 2758
Joined: Mon Jan 30, 2017 8:37 am

Re: COVID-19

Post by Jason »

I was listening to an interview with a highly credentialized scientist on the matter. One of the first people to handle an AIDS patient. Was honest in that his expertise in this corona is three months old. His macro picture was concerning. Essentially, this has been a Northern Hemisphere event. It's inevitable entry into the Southern Hemisphere (Spring/Summer) will be cataclysmic due to fragile infrastructure. It will then recirculate to the North (Fall/Winter).

ertyu
Posts: 919
Joined: Sun Nov 13, 2016 2:31 am

Re: COVID-19

Post by ertyu »

The only silver lining here would be if the temporary pause over the summer lets hospitals and gvts catch up on preparedness. Shit's not looking good, though - someone elsewhere on the internet was talking about hospital stocks tanking because of corona patients who are low margin displacing patients with more lucrative diseases to treat. Hospital mgt thus incentivised to skimp on ppe and not purchase equipment that will not be required past the duration of the epidemic.

Seppia
Posts: 1416
Joined: Tue Aug 30, 2016 9:34 am
Location: Italy

Re: COVID-19

Post by Seppia »

ertyu wrote:
Sun Mar 29, 2020 12:03 pm
Hospital mgt thus incentivised to skimp on ppe and not purchase equipment that will not be required past the duration of the epidemic.
Another great side effect of a privatized healthcare system

George the original one
Posts: 5335
Joined: Wed Jul 28, 2010 3:28 am
Location: Wettest corner of Orygun

Re: COVID-19

Post by George the original one »

George the original one wrote:
Sat Mar 28, 2020 3:23 pm
Oregon Health Authority as of 9:30a Sat, Mar 28
- 479 Positives
- 9693 Negatives
- 13 Deaths

Cases by County
- 8 Benton (Corvallis) - Note two are actually in Washington state, though they're residents of Benton County.
- 36 Clackamas (Oregon City)
- 3 Clatsop (Astoria)
- 1 Columbia (St. Helens)
- 20 Deschutes (Bend)
- 4 Douglas (Roseburg)
- 1 Grant (Canyon City)
- 1 Hood River (Hood River)
- 8 Jackson (Medford)
- 5 Josephine (Grants Pass)
- 2 Klamath (Klamath Falls)
- 9 Lane (Eugene)
- 1 Lincoln (Newport)
- 32 Linn (Albany)
- 94 Marion (Salem)
- 1 Morrow (Heppner)
- 81 Multnomah (Portland)
- 11 Polk (Dallas)
- 1 Tillamook (Tillamook)
- 4 Umatilla (Pendleton)
- 1 Union (La Grande)
- 2 Wasco (The Dalles)
- 140 Washington (Hillsboro)
- 13 Yamhill (McMinnville)

Cases by Age Group
- 10 19 or younger
- 39 20-29
- 60 30-39
- 95 40-49
- 91 50-59
- 92 60- 69
- 49 70-79
- 42 80 and over
- 1 Not available

Hospitalized by Age Group
- 0 19 or younger
- 3 20-29
- 5 30-39
- 21 40-49
- 16 50-59
- 33 60- 69
- 23 70-79
- 16 80 and over
- 0 Not available

Hospitalized
- 117 Yes
- 266 No
- 96 Not provided

Sex
- 260 Male
- 214 Male
- 5 Not available

Hospital Capacity
- 283 Available adult ICU beds
- 2099 Available adult non-ICU beds
- 189 Available pediatric beds
- 68 Available pediatric ICU beds
- 746 Available ventilators
- 107 COVID-19 admissions
- 31 COVID-19 patients on ventilators
69 new cases. Bit of a surge in Jackson County (Medford).

Oregon Health Authority as of 8:00a Sun, Mar 29
- 548 Positives
- 10878 Negatives
- 13 Deaths

Cases by County
- 8 Benton (Corvallis) - Note two are actually in Washington state, though they're residents of Benton County.
- 39 Clackamas (Oregon City)
- 3 Clatsop (Astoria)
- 1 Columbia (St. Helens)
- 23 Deschutes (Bend)
- 4 Douglas (Roseburg)
- 1 Grant (Canyon City)
- 2 Hood River (Hood River)
- 19 Jackson (Medford)
- 6 Josephine (Grants Pass)
- 4 Klamath (Klamath Falls)
- 10 Lane (Eugene)
- 1 Lincoln (Newport)
- 36 Linn (Albany)
- 109 Marion (Salem)
- 1 Morrow (Heppner)
- 91 Multnomah (Portland)
- 13 Polk (Dallas)
- 2 Tillamook (Tillamook)
- 4 Umatilla (Pendleton)
- 1 Union (La Grande)
- 3 Wasco (The Dalles)
- 154 Washington (Hillsboro)
- 13 Yamhill (McMinnville)

Cases by Age Group
- 10 19 or younger
- 49 20-29
- 70 30-39
- 103 40-49
- 109 50-59
- 101 60- 69
- 59 70-79
- 45 80 and over
- 2 Not available

Hospitalized by Age Group
- 0 19 or younger
- 4 20-29
- 6 30-39
- 25 40-49
- 17 50-59
- 34 60- 69
- 25 70-79
- 18 80 and over
- 0 Not available

Hospitalized
- 129 Yes
- 316 No
- 103 Not provided

Sex
- 306 Female
- 236 Male
- 6 Not available

Hospital Capacity
- 285 Available adult ICU beds
- 2010 Available adult non-ICU beds
- 193 Available pediatric beds
- 66 Available pediatric ICU beds
- 767 Available ventilators
- 142 COVID-19 admissions
- 37 COVID-19 patients on ventilators

User avatar
Ego
Posts: 4809
Joined: Wed Nov 23, 2011 12:42 am

Re: COVID-19

Post by Ego »

Seppia wrote:
Sun Mar 29, 2020 12:06 pm
Another great side effect of a privatized healthcare system
Just spoke with a nurse friend who is at a hospital with 20 Covid positives. He in oncology and they are still treating regular oncology patients. They have not yet shifted them to a temporary facility.

He has been contacted by several headhunters offering $5500 per week plus housing to relocate to Seattle.

thrifty++
Posts: 1085
Joined: Sat May 23, 2015 3:46 pm

Re: COVID-19

Post by thrifty++ »

Is anyone on here in New Caledonia? I feel like that is the place I would most want to be right now. Provided borders are closed to France. Are they? It looks barely unaffected by covid19. And it doesn't ever get cold there which will be nice with southern hemisphere winter on its way. How are things in New Caledonia now?

George the original one
Posts: 5335
Joined: Wed Jul 28, 2010 3:28 am
Location: Wettest corner of Orygun

Re: COVID-19

Post by George the original one »

Can anyone explain the logic of the UK lockdown leaving dry cleaners open?!?

Also, I didn't pay enough attention to Australian states going to stage 2. Did they all do it at once and when? Australia is definitely an interesting case because of the extreme population distribution.

chenda
Posts: 1442
Joined: Wed Jun 29, 2011 1:17 pm

Re: COVID-19

Post by chenda »

George the original one wrote:
Sun Mar 29, 2020 3:54 pm
Can anyone explain the logic of the UK lockdown leaving dry cleaners open?!?
I assume its considered neccessary to sterilise towels and clothes and things, and the premises I think fall under the same use class as laundrettes.

Noal
Posts: 36
Joined: Sat Jun 02, 2018 3:08 am

Re: COVID-19

Post by Noal »

I'd imagine Chenda is correct. There will be lots of people that perhaps don't even have a washing machine. I'm thinking about big share houses and the like. In the UK, dry cleaners and laundrettes are essentially the same thing. You don't see too many of those laundrette shops with a pile of coin operated washer driers.

7Wannabe5
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Location: Clinton River Watershed

Re: COVID-19

Post by 7Wannabe5 »

In today’s White House press conference, Dr. Birks stated that CDC independent analysis of incoming U.S. data was very much in alignment with the IHME projections Jacob linked above.

So relieved the U.S. will be moving forward based on this model!

George the original one
Posts: 5335
Joined: Wed Jul 28, 2010 3:28 am
Location: Wettest corner of Orygun

Re: COVID-19

Post by George the original one »

7Wannabe5 wrote:
Sun Mar 29, 2020 6:07 pm
So relieved the U.S. will be moving forward based on this model!
Relieved, but look at how huge the uncertainty cloud is when you look ahead more than two weeks! I mean, for Oregon at the peak, they're estimating we'll need from 65 to 3,000+ beds.

thrifty++
Posts: 1085
Joined: Sat May 23, 2015 3:46 pm

Re: COVID-19

Post by thrifty++ »

76 new cases in NZ leading to 589 total probable and confirmed cases.

Average of 1,728 tests per day being done.

12 in hospital expecting to be released soon - but still only one person in serious/critical condition.

3 people have been arrested for breaching lock down rules.

So that's a fatality rate of 0.17% and a serious/critical rate of 0.34%. Hopefully things continue this way.

There was a group of 60 backpackers at a party that the police attended in Queenstown. Really ticks me off. They should all be put into quarantine and deported.

bostonimproper
Posts: 213
Joined: Sun Jul 01, 2018 11:45 am

Re: COVID-19

Post by bostonimproper »

Devastating effect of misinformation: hundreds die in Iran from drinking methanol, trying to prevent coronavirus.

Tyler9000
Posts: 1666
Joined: Fri Jun 01, 2012 11:45 pm

Re: COVID-19

Post by Tyler9000 »

Novartis CEO says Malaria drug is biggest hope against coronavirus

"Pre-clinical studies in animals as well as the first data from clinical studies show that hydroxychloroquine kills the coronavirus," Narasimhan told the newspaper.

https://finance.yahoo.com/news/novartis ... 52054.html

classical_Liberal
Posts: 1663
Joined: Sun Mar 20, 2016 6:05 am

Re: COVID-19

Post by classical_Liberal »

Ego wrote:
Sun Mar 29, 2020 3:21 pm
He has been contacted by several headhunters offering $5500 per week plus housing to relocate to Seattle.
Also, thats net pay. Nurse travelverse for ICU has 5K weekly net contracts in many places at this point. Temp lifting of license restrictions cuts down on the BS/waste of time bureaucratic nonsense. The only time I've seen contracts paying this much have been very temporary union strike busting gigs.

CS
Posts: 554
Joined: Sat Dec 29, 2012 10:24 pm

Re: COVID-19

Post by CS »

That is definitely war wages. I think oncology is going to take a bit hit over the next 12-18 months unless they can get some mandatory testing in place - it is by definition a department of high risk people.

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